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0 Day 0 Day 28 2 4 6 8 Average Mouth Plaque Scores Day 56 Average Mouth Score 39 % reduction* 42 % reduction* P<0.01 10 12 0 Day 0 Day 28 0.2 0.6 0.8 1.2 Average Mouth Calculus Scores Day 56 Average Mouth Score 57 % reduction* 54 % reduction* P<0.01 0.4 1 1.4 1.6 1.8 2 Scoring for plaque reduction based on the combined scores of gingival and occlusal halves (eg, whole tooth) at Days 28 and 56. Block Plaque, Calculus, and Halitosis with the Science of Proven Prevention • A statistically significant (P<0.01) reduction in plaque was recorded for the dogs offered the delmopinol- coated chew compared to the dogs that received the dry diet only. On day 56, the mean mouth plaque reduction of dogs offered the delmopinol chew was 42.1% when compared to the control group. 3 Study Design: Study dogs underwent a dental scaling and polishing 7 days prior to the start of the study. On study Day 0, halitosis, plaque, and calculus were evaluated, and dogs were stratified by their baseline plaque scores into 3 groups to receive: 1) Dry diet alone, 2) Dry diet and an uncoated chew, and 3) Dry diet and a delmopinol-coated chew. Each dog underwent another dental cleaning and polishing to ensure a clean mouth at the start of the test phase (56-day study period). Outcome measures (eg, plaque and calculus formation and halitosis) were evaluated at Days 28 and 56. 3 † Study was conducted with a prototype dental chew. 3. Rundegren J. and Arnebrant T. Effect of delmopinol on the viscosity of extracellular glucans produced by Streptococcus mutans. Caries Res. 1992;26(4):281-285. • A statistically significant (P<0.01) reduction in calculus was recorded for the dogs offered the delmopinol- coated chew compared to the dogs that received the dry diet only. On day 56, the mean mouth calculus reduction of dogs offered the delmopinol chew was 53.8% when compared to the control group. 3 0 Day 0 Day 28 10 20 30 40 Average Mouth Halitosis Scores Day 56 Average Mouth Score (ppb) 59 % reduction* 53 % reduction* P<0.01 P<0.01 50 60 Dry Diet Alone Dry Diet + OraVet Dental Hygiene Chews † • A statistically significant (P<0.01) reduction in halitosis was recorded for the dogs offered the delmopinol- coated chew compared to the dogs that received the dry diet only. On day 56, the mean mouth halitosis reduction for dogs offered the delmopinol chew was 52.5% when compared to the control group. 3 State the Solution Giving Spot ORAVET Dental Chews once daily will make it easy to block plaque, calculus, and halitosis. Make Your Recommendation I recommend ORAVET for Serious Oral Care Made Simple ® . Do you have any questions? If engaging in an initial diagnosis, start with: Ms. Jones, it looks like Spot is showing signs of plaque build-up and bad breath. Start an Effective Team to Pet Owner Conversation